化合物TCN 238
TCN 238(TCN 238)
CAS: 125404-04-8
化学式: C12H11N3
| 中文名 | TCN 238 |
| 英文名 | TCN 238 |
| 别名 | 化合物TCN 238 |
| 英文别名 | TCN 238 TCN-238 Lu AF32615 4-Styryl-pyrimidin-2-ylamine (E)-4-(2-Phenylethenyl)-2-pyriMidinaMine 2-PyriMidinaMine, 4-(2-phenylethenyl)-, (E)- 2-PyriMidinaMine, 4-(2-phenylethenyl)-, (E)- (9CI) |
| CAS | 125404-04-8 |
| 化学式 | C12H11N3 |
| 分子量 | 197.24 |
| 存储条件 | 2-8℃ |
| 体外研究 | In the rat mGlu4 PAM in vitro assay the EC 50 of TCN238 (Compound 11) is 1 μM which is comparable to the human assay. TCN238 is screened in rat and human mGlu5 assays, the IC 50 of 11 is >30 μM on human mGlu5and >10 μM on rat mGlu5. TCN238 is run in a receptor screening panel of 68 targets and no activity is observed at ≥50% at 10 μM for any of the receptors. In CaCo-2 cells, TCN238 is found to have good permeability with no apparent efflux issue. |
| 体内研究 | TCN238 is highly CNS penetrant with a concentration of 33.8 μM in the brain. The plasma protein binding in rats is measured as 90% bound. The metabolic stability of TCN238 is assessed in rat and human microsomes and found to be 62% and 83% hepatic blood flow. The limited stability translated into a high in vivo clearance in rats of 75 mL/min/kg and TCN238 has a moderate volume of distribution (2.7 L/kg) with a short mean residence time (0.6 h) when dosed at 2 mg/kg via intravenous injection. TCN238 is orally bioavailable and 30 min following administration of a30 mg/kg dose, the plasma concentration is found to be 11.6 μM. TCN 238 does not affect the performance of the learned task. However, the expression level of GRM4 in the hippocampus is reliable down-regulated five days after treatment with TCN 238. In addition, the expression level of GABRA1, encoding GABAA α-subunit is downregulated five days after the treatment in the frontal cortex. |
化合物TCN 238 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 5.07 ml | 25.35 ml | 50.7 ml |
| 5 mM | 1.014 ml | 5.07 ml | 10.14 ml |
| 10 mM | 0.507 ml | 2.535 ml | 5.07 ml |
| 5 mM | 0.101 ml | 0.507 ml | 1.014 ml |
最后更新：2024-01-02 23:10:35
化合物TCN 238 - 简介
TCN 238的主要用途是作为高能爆炸物的组分之一，常用于军事领域和爆破工程中。其高爆炸性，它被广泛应用于火药、炸药和火箭推进剂等领域。
制备TCN 238的方法包括通过硝酸对苯进行硝化反应。具体制法是将苯置于硝化混合酸（通常为硝酸和浓硫酸的混合物）中反应。
值得注意的是，TCN 238具有极高的爆炸性，潜在的危险性也很高。在制备过程中需要遵循严格的安全操作规程，如低温下进行反应，远离火源以及避免与其他易燃物接触。对于使用和储存TCN 238的场合，必须进行严格的安全管理和保护措施，以避免意外事故的发生。
最后更新：2024-04-10 22:29:15
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